Understanding GGTaseII: Enzyme Involved in Plant Natural Product Synthesis

Target Name: Protein geranylgeranyltransferase type II

NCBI ID: P14138

Other Name(s): GGTaseII | Rab geranylgeranyl transferase | Geranylgeranyl-diphosphate:protein-cysteine geranyltransferase | Rab-GGTase

Understanding GGTaseII: Enzyme Involved in Plant Natural Product Synthesis

Protein GeranylgeranylTransferase Type II (GGTaseII) is an enzyme that plays a crucial role in the synthesis of natural products in plants, such as ginger, basil, and other herbs. GGTaseII is an enzyme that transfers ageranyl group from the amino acid leucine to the alpha -amino acid geranyl, which is then incorporated into the target molecule.

GGTaseII is an enzyme that is expressed in most plant species, including humans. It is found in the highest concentrations in the roots and followed by the leaves. GGTaseII is also expressed in the stems and roots of some varieties of plants, but its level is lower than in the leaves or roots.

The activity of GGTaseII can be inhibited by various factors, such as temperature, pH, and substrate concentration. At room temperature, the activity of GGTaseII is around 200 units per liter per minute (U/ml), while it increases to around 400 U /ml at pH 7.5. The substrate concentration also has an effect on the activity of GGTaseII, with higher concentrations of the substrate leading to higher activity.

GGTaseII has been shown to be involved in the synthesis of various natural products in plants, including ginger, basil, and other herbs. Ginger is a popular herb that is known for its healing properties and is widely used in Asian cuisine. The ginger spice that is commonly used in cooking is derived from the rhizome of the plant Zingiber officinale, which is characterized by the presence of GGTaseII.

GGTaseII has also been shown to be involved in the synthesis of other natural products in plants, such as the alkaloid esculetine in the compound-Ranunculus genus. Esculetine is a natural compound that is found in various plants, including ginger, and has been shown to have various therapeutic effects.

GGTaseII has also been shown to play a role in the regulation of various cellular processes in plants. For example, GGTaseII has been shown to be involved in the regulation of cell wall formation in plants, as well as in the regulation of ion homeostasis.

GGTaseII has also been shown to be involved in the detoxification of various xenobiotics in plants. the toxic compound aminofluorobutyric acid (AFB), which is commonly used in the production of various industrial chemicals.

Despite its importance in the synthesis of natural products and the regulation of various cellular processes, GGTaseII is not yet a drug target or biomarker. There is a need for further research to better understand the role of GGTaseII in plant synthesis and its potential as a drug or biomarker.

In conclusion, GGTaseII is an enzyme that plays a crucial role in the synthesis of natural products in plants. It is expressed in most plant species and is involved in the transfer of thegeranyl group from the amino acid leucine to the alpha-amino acid geranyl. GGTaseII is also involved in the regulation of various cellular processes in plants, as well as in the detoxification of various xenobiotics. Further research is needed to better understand the role of GGTaseII as a drug target or biomarker.

Protein Name: Protein Geranylgeranyltransferase Type II

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